"Berberine is an active constituent of many plants including Phellodendron amurense root. Berberine activates adenosine monophosphate kinase (AMPK). AMPK is activated through various mechanisms including exercise to support glucose metabolism via an insulin-independent mechanism. Berberine has been the subject of human, randomized placebo-controlled trials. These plants have been used in traditional Chinese and other herbal medicine systems for centuries. More recent characterization and isolation of the main active constituent, berberine, has led to the development of this Berberine hydrochloride supplement. Each capsule contains 500 mg berberine hcl. Berberine supports healthy: blood sugar metabolism and insulin metabolism* metabolic function* cardiovascular function and lipid metabolism* insulin receptor expression, with direct impact on supporting healthy glucose metabolism* regulation of glycation*"